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The Melanocortin-1 Receptor is a Key Regulator of Human Cutaneous Pigmentation

ZALFA ABDEL-MALEK, M. CATHY SCOTT, ITARU SUZUKI, AKIHIRO TADA, SUNGBIN IM, LYNN LAMOREUX, SHOSUKE ITO, GREG BARSH, VINCENT J. HEARING

Journal:

Pigment Cell & Melanoma Research

Année:

2000

Langue:

english

Fichier:

PDF, 171 KB

english, 2000

Production of Melanocyte-Specific Antibodies to Human Melanosomal Proteins: Expression Patterns in Normal Human Skin and in Cutaneous Pigmented Lesions

Victoria Virador, Naoko Matsunaga, Jun Matsunaga, Julio Valencia, Roger J. Oldham, Koichiro Kameyama, Gary L. Peck, Victor J. Ferrans, Wilfred D. Vieira, Zalfa A. Abdel-Malek, Vincent J. Hearing

Journal:

Pigment Cell & Melanoma Research

Année:

2001

Langue:

english

Fichier:

PDF, 21.68 MB

english, 2001

Hormonal effects of vitamin D3 on epidermal melanocytes

Zalfa A. Abdel-Malek, Richard Ross, Linda Trinkle, Viki Swope, John W. Pike, James J. Nordlund

Journal:

Journal of Cellular Physiology

Année:

1988

Langue:

english

Fichier:

PDF, 843 KB

english, 1988

Mitogenic, melanogenic, and cAMP responses of cultured neonatal human melanocytes to commonly used mitogens

Zalfa Abdel-Malek, Viki B. Swope, James Pallas, Kimberly Krug, James J. Nordlund

Journal:

Journal of Cellular Physiology

Année:

1992

Langue:

english

Fichier:

PDF, 1.30 MB

english, 1992

Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes

Jennifer E. Hauser, Ana Luisa Kadekaro, Renny J. Kavanagh, Kazumasa Wakamatsu, Silva Terzieva, Sandy Schwemberger, George Babcock, M. B. Rao, Shosuke Ito, Zalfa A. Abdel-Malek

Journal:

Pigment Cell & Melanoma Research

Année:

2006

Langue:

english

Fichier:

PDF, 297 KB

english, 2006

The Melanocortin-1 Receptor and Human Pigmentation

ZALFA ABDEL-MALEK, ITARU SUZUKI, AKIHIRO TADA, SUNGBIN IM, CAN AKCALI

Journal:

Annals of the New York Academy of Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 592 KB

english, 1999

Significance of the Melanocortin 1 Receptor in Regulating Human Melanocyte Pigmentation, Proliferation, and Survival

ANA LUISA KADEKARO, HIROMI KANTO, RENNY KAVANAGH, ZALFA A. ABDEL-MALEK

Journal:

Annals of the New York Academy of Sciences

Année:

2003

Fichier:

PDF, 195 KB

2003

MC1R and the response of melanocytes to ultraviolet radiation

Francois Rouzaud, Ana Luisa Kadekaro, Zalfa A. Abdel-Malek, Vincent J. Hearing

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2005

Langue:

english

Fichier:

PDF, 397 KB

english, 2005

α-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes

Zalfa A. Abdel-Malek, Andrew Ruwe, Renny Kavanagh-Starner, Ana Luisa Kadekaro, Viki Swope, Carrie Haskell-Luevano, Leonid Koikov, James J. Knittel

Journal:

Pigment Cell & Melanoma Research

Année:

2009

Langue:

english

Fichier:

PDF, 365 KB

english, 2009

Beyond Red Hair and Sunburns: Uncovering the Molecular Mechanisms of MC1R Signaling and Repair of UV-Induced DNA Damage

Cassidy, Pamela B, Abdel-Malek, Zalfa A, Leachman, Sancy A

Journal:

The Journal of Investigative Dermatology

Année:

2015

Langue:

english

Fichier:

PDF, 210 KB

english, 2015

Dark CPDs and photocarcinogenesis: the party continues after the lights go out

Abdel-Malek, Zalfa A., Cassidy, Pamela

Journal:

Pigment Cell & Melanoma Research

Année:

2015

Langue:

english

Fichier:

PDF, 36 KB

english, 2015

Chemoprevention agents for melanoma: a path forward into phase 3 clinical trials

Jeter, Joanne M., Bowles, Tawnya L., Curiel-Lewandrowski, Clara, Swetter, Susan M., Filipp, Fabian V., Abdel-Malek, Zalfa A., Geskin, Larisa J., Brewer, Jerry D., Arbiser, Jack L., Gershenwald, Jeffre

Journal:

Cancer

Année:

2018

Langue:

english

Fichier:

PDF, 541 KB

english, 2018

The Enigma and Challenges of Vitiligo Pathophysiology and Treatment

Abdel-Malek, Zalfa A., Jordan, Christian, Ho, Tina, Upadhyay, Parth Rajendrakumar, Fleischer, Alan, Hamzavi, Iltefat

Journal:

Pigment Cell & Melanoma Research

Année:

2020

Langue:

english

Fichier:

PDF, 13.47 MB

english, 2020

D-Isomeric replacements within the 6–9 core sequence of ac-[Nle4]-α-MSH4–11-NH2: A topological model for the solution conformation of α-melanotropin

Elizabeth E. Sugg, Wayne L. Cody, Zalfa Abdel-Malek, Mac E. Hadley, Victor J. Hruby

Journal:

Biopolymers

Année:

1986

Langue:

english

Fichier:

PDF, 809 KB

english, 1986

Differentiation of mitotic melanoma cells from G2 cells and their isolation by use of 5-bromo-2′-deoxyuridine and propidium iodide

Linda S. Trinkle, Viki B. Swope, Zalfa A. Abdel-Malek, James J. Nordlund

Journal:

Cytometry Part A

Année:

1988

Langue:

english

Fichier:

PDF, 545 KB

english, 1988

Alteration of the Cloudman melanoma cell cycle by prostaglandins E1 and E2 determined by using a 5-bromo-2′-deoxyuridine method of DNA analysis

Zalfa A. Abdel-Malek, Viki B. Swope, Linda S. Trinkle, Elisabeth N. Ferroni, Raymond E. Boissy, James J. Nordlund

Journal:

Journal of Cellular Physiology

Année:

1988

Langue:

english

Fichier:

PDF, 1.06 MB

english, 1988

Semi-rigid tripeptide agonists of melanocortin receptors

Andrew R. Ruwe, Leonid Koikov, Zalfa Abdel-Malek, Carrie Haskell-Luevano, Marvin L. Dirain, Federico Portillo, Zhimin Xiang, Matt Wortman, James J. Knittel

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 658 KB

english, 2009

Neuromediators and pigmentation

Zalfa Abdel-Malek Ph.D.

Journal:

Experimental Dermatology

Année:

2001

Langue:

english

Fichier:

PDF, 159 KB

english, 2001

Regulation of the Human Melanocortin 1 Receptor Expression in Epidermal Melanocytes by Paracrine and Endocrine Factors and by Ultraviolet Radiation

M. Cathy Scott, Itaru Suzuki, Zalfa A. Abdel-Malek

Journal:

Pigment Cell & Melanoma Research

Année:

2002

Langue:

english

Fichier:

PDF, 152 KB

english, 2002

Cutaneous Photobiology. The Melanocyte vs. the Sun: Who Will Win the Final Round?

Ana Luisa Kadekaro, Renny J. Kavanagh, Kazumasa Wakamatsu, Shosuke Ito, Michelle A. Pipitone, Zalfa A. Abdel-Malek

Journal:

Pigment Cell & Melanoma Research

Année:

2003

Langue:

english

Fichier:

PDF, 579 KB

english, 2003

Mitogen- and Ultraviolet-B-Induced Signaling Pathways in Normal Human Melanocytes

Tada, Akihiro, Pereira, Elizabeth, Beitner-Johnson, Dana, Kavanagh, Renny, Abdel-Malek, Zalfa A.

Journal:

The Journal of Investigative Dermatology

Année:

2002

Langue:

english

Fichier:

PDF, 224 KB

english, 2002

Identification and Sequencing of a Putative Variant of Proopiomelanocortin in Human Epidermis and Epidermal Cells in Culture

Can, Gong, Abdel-Malek, Zalfa, Porter-Gill, Patricia A, Gill, Pritmohinder, Boyce, Steven, Grabowski, Gregory A, Nordlund, James, Farooqui, Jamal

Journal:

The Journal of Investigative Dermatology

Année:

1998

Langue:

english

Fichier:

PDF, 576 KB

english, 1998

Effects of commonly used mitogens on the cytotoxicity of 4-tertiary butylphenol to human melanocytes

Fan Yang, Zalfa Abdel-Malek, Raymond E. Boissy

Journal:

In Vitro Cellular & Developmental Biology - Animal

Année:

1999

Langue:

english

Fichier:

PDF, 563 KB

english, 1999

Agouti Signaling Protein Inhibits Melanogenesis and the Response of Human Melanocytes to α-Melanotropin

Suzuki, Itaru, Tada, Akihiro, Ollmann, Michael M, Barsh, Gregory S, Im, Sungbin, Lamoreux, M Lynn, Hearing, Vincent J, Nordlund, James J, Abdel-Malek, Zalfa A

Journal:

The Journal of Investigative Dermatology

Année:

1997

Fichier:

PDF, 2.00 MB

1997

Interleukins 1alpha and 6 and Tumor Necrosis Factor-alpha Are Paracrine Inhibitors of Human Melanocyte Proliferation and Melanogenesis.

Swope, Viki B., Abdel-Malek, Zalfa, Kassem, Lina M., Nordlund, James J.

Journal:

The Journal of Investigative Dermatology

Année:

1991

Fichier:

PDF, 3.47 MB

1991

Pigmentation and Inhibition of Wound Contraction by Cultured Skin Substitutes with Adult Melanocytes After Transplantation to Athymic Mice.

Boyce, Steven T., Medrano, Estela E., Abdel-Malek, Zalfa, Supp, Andrew P., Dodick, JoAnn M., Nordlund, James J., Warden, Glenn D.

Journal:

The Journal of Investigative Dermatology

Année:

1993

Fichier:

PDF, 3.55 MB

1993

PGE2 is a UVR-inducible autocrine factor for human melanocytes that stimulates tyrosinase activation

Renny J. Starner, Lindy McClelland, Zalfa Abdel-Malek, Alex Fricke, Glynis Scott

Journal:

Experimental Dermatology

Année:

2010

Langue:

english

Fichier:

PDF, 276 KB

english, 2010

Role of the Melanocyte in Epidermal Inflammatory and Immune Responses

JAMES J. NORDLUND, SOMNUK AMORNSIRIPANITCH, LAWRENCE A. RHEINS, ZALFA A. ABDEL-MALEK, RAYMOND E. BOISSY, MARY BELL

Journal:

Pigment Cell & Melanoma Research

Année:

1988

Langue:

english

Fichier:

PDF, 1.59 MB

english, 1988

The Nature and Biological Effects of Factors Responsible for Proliferation and Differentiation of Melanocytes

Zalfa A. Abdel-Malek, Viki B. Swope, James J. Nordlund

Journal:

Pigment Cell & Melanoma Research

Année:

1990

Langue:

english

Fichier:

PDF, 538 KB

english, 1990

Proliferation and Propagation of Human Melanocytes in Vitro Are Affected by Donor Age and Anatomical Site

ZALFA A. ABDEL-MALEK, VIKI B. SWOPE, JAMES J. NORDLUND, ESTELA E. MEDRANO

Journal:

Pigment Cell & Melanoma Research

Année:

1994

Langue:

english

Fichier:

PDF, 813 KB

english, 1994

Analysis of the UV-Induced Melanogenesis and Growth Arrest of Human Melanocytes

ZALFA ABDEL-MALEK, VIKI SWOPE, DOUGLAS SMALARA, GEORGE BABCOCK, SUSAN DAWES, JAMES NORDLUND

Journal:

Pigment Cell & Melanoma Research

Année:

1994

Langue:

english

Fichier:

PDF, 729 KB

english, 1994

The Interaction of Agouti Signal Protein and Melanocyte Stimulating Hormone to Regulate Melanin Formation in Mammals

MINAO FURUMURA, CHIE SAKAI, ZALFA ABDEL-MALEK, GREGORY S. BARSH, VINCENT J. HEARING

Journal:

Pigment Cell & Melanoma Research

Année:

1996

Langue:

english

Fichier:

PDF, 1.52 MB

english, 1996

Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin

Kazumasa Wakamatsu, Renny Kavanagh, Ana L. Kadekaro, Silva Terzieva, Richard A. Sturm, Sancy Leachman, Zalfa Abdel-Malek, Shosuke Ito

Journal:

Pigment Cell & Melanoma Research

Année:

2006

Langue:

english

Fichier:

PDF, 300 KB

english, 2006

Walking in the footsteps of giants: melanocortins and human pigmentation, a historical perspective

Ana Luisa Kadekaro, Zalfa A. Abdel-Malek

Journal:

Pigment Cell & Melanoma Research

Année:

2007

Langue:

english

Fichier:

PDF, 435 KB

english, 2007

The Melanocortin 1 Receptor and the UV Response of Human Melanocytes—A Shift in Paradigm

Zalfa A. Abdel-Malek, James Knittel, Ana Luisa Kadekaro, Viki B. Swope, Renny Starner

Journal:

Photochemistry and Photobiology

Année:

2008

Langue:

english

Fichier:

PDF, 158 KB

english, 2008

Long-Term Proliferation of Human Melanocytes Is Supported by the Physiologic Mitogens α-Melanotropin, Endothelin-1, and Basic Fibroblast Growth Factor

Viki B. Swope, Estela E. Medrano, Douglas Smalara, Zalfa A. Abdel-Malek

Journal:

Experimental Cell Research

Année:

1995

Fichier:

PDF, 654 KB

1995

α-Melanocyte-Stimulating Hormone and Endothelin-1 Have Opposing Effects on Melanocyte Adhesion, Migration, and pp125FAKPhosphorylation

Glynis Scott, Linda Cassidy, Zalfa Abdel-Malek

Journal:

Experimental Cell Research

Année:

1997

Langue:

english

Fichier:

PDF, 1.30 MB

english, 1997

Stimulation of cloudman melanoma tyrosinase activity occurs predominantly in G2 phase of the cell cycle

Zalfa A. Abdel-malek, Viki B. Swope, Linda S. Trinkle, James J. Nordlund

Journal:

Experimental Cell Research

Année:

1989

Langue:

english

Fichier:

PDF, 963 KB

english, 1989

β-Defensin 3: a novel and unexpected key that unlocks the melanocortin 1 receptor

Zalfa A. Abdel-Malek, Dorothy Supp

Journal:

Pigment Cell & Melanoma Research

Année:

2008

Langue:

english

Fichier:

PDF, 39 KB

english, 2008

Agouti signal protein: crossing the ‘yellow’ signal and arriving to pathways that affect tumorgenesis

Zalfa A. Abdel-Malek

Journal:

Pigment Cell & Melanoma Research

Année:

2009

Langue:

english

Fichier:

PDF, 34 KB

english, 2009

α-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes

Xiuzu Song, Nicole Mosby, Jennifer Yang, Aie Xu, Zalfa Abdel-Malek, Ana Luisa Kadekaro

Journal:

Pigment Cell & Melanoma Research

Année:

2009

Langue:

english

Fichier:

PDF, 497 KB

english, 2009

Stepping up melanocytes to the challenge of UV exposure

Zalfa A. Abdel-Malek, Ana Luisa Kadekaro, Viki B. Swope

Journal:

Pigment Cell & Melanoma Research

Année:

2010

Langue:

english

Fichier:

PDF, 206 KB

english, 2010

Estela Medrano, 1943–2010

Zalfa Abdel-Malek, Menashe Bar-Eli

Journal:

Pigment Cell & Melanoma Research

Année:

2010

Langue:

english

Fichier:

PDF, 51 KB

english, 2010

The role of calcium signaling in mediating the mitogenic and melanogenic effects of endothelin-1 on human melanocytes

Tada, Akihiro, Suzuki, Itaru, Abdel-Malek, Zalfa

Journal:

Journal of Dermatological Science

Année:

1998

Langue:

english

Fichier:

PDF, 203 KB

english, 1998

The Expression of Proopiomelanocortin and Various POMC-Derived Peptides in Mouse and Human Skin

JAMAL Z. FAROOQUI, ESTELA E. MEDRANO, ZALFA ABDEL-MALEK, JAMES NORDLUND

Journal:

Annals of the New York Academy of Sciences

Année:

1993

Langue:

english

Fichier:

PDF, 238 KB

english, 1993

N-Terminal Fatty Acylated His- d Phe-Arg-Trp-NH 2 Tetrapeptides: Influence of Fatty Acid Chain Length on Potency and Selectivity at the Mouse Melanocortin Receptors and Human Melanocytes

Todorovic, Aleksandar, Holder, Jerry Ryan, Bauzo, Rayna M., Scott, Joseph Walker, Kavanagh, Renny, Abdel-Malek, Zalfa, Haskell-Luevano, Carrie

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 234 KB

english, 2005

Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention

Abdel-Malek, Zalfa A., Swope, Viki B., Starner, Renny J., Koikov, Leonid, Cassidy, Pamela, Leachman, Sancy

Journal:

Archives of Biochemistry and Biophysics

Année:

2014

Langue:

english

Fichier:

PDF, 1.39 MB

english, 2014

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation

García-Borrón, Jose C., Abdel-Malek, Zalfa, Jiménez-Cervantes, Celia

Journal:

Pigment Cell & Melanoma Research

Année:

2014

Langue:

english

Fichier:

PDF, 7.97 MB

english, 2014

Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation

Swope, Viki, Alexander, Christina, Starner, Renny, Schwemberger, Sandy, Babcock, George, Abdel-Malek, Zalfa A.

Journal:

Pigment Cell & Melanoma Research

Année:

2014

Langue:

english

Fichier:

PDF, 7.82 MB

english, 2014

Being in the red: a no-win situation with melanoma

Abdel-Malek, Zalfa A., Ito, Shosuke

Journal:

Pigment Cell & Melanoma Research

Année:

2013

Langue:

english

Fichier:

PDF, 42 KB

english, 2013